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Literature summary for 2.8.2.20 extracted from
- Tyrosine sulfation of arylsulfatase A and its peptide (2006), Protein Pept. Lett., 13, 357-361.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
statherin | pH 6.5, 37°C | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | activates, optimal at 20 mM, not essential | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + statherin | Homo sapiens | TPST is responsible for the sulfation of a variety of secretory and membrane proteins, e.g. of the salivary secretory protein, statherin | adenosine 3',5'-bisphosphate + statherin O-sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| saliva | - |
Homo sapiens | - |
| submandibular gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + poly-Glu6Ala3Tyr1 peptide | - |
Homo sapiens | adenosine 3',5'-bisphosphate + poly-Glu6Ala3Tyrsulfate peptide | - |
? | |
| 3'-phosphoadenylyl sulfate + statherin | TPST is responsible for the sulfation of a variety of secretory and membrane proteins, e.g. of the salivary secretory protein, statherin | Homo sapiens | adenosine 3',5'-bisphosphate + statherin O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + statherin | determination of sulfation on a tyrosyl residue, probably in the sequence E-Q-P-L-Y, residues 26-30 | Homo sapiens | adenosine 3',5'-bisphosphate + statherin O-sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPST | - |
Homo sapiens |
| tyrosylprotein sulfotransferase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Homo sapiens |
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Release 2023.1 (January 2023)
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