Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-dibromophenol | - |
Lithobates catesbeianus | |
2,6-Dichloro-4-nitrophenol | - |
Lithobates catesbeianus | |
2,6-dichlorophenol | - |
Lithobates catesbeianus | |
ioxynil | - |
Lithobates catesbeianus | |
additional information | nonylphenol and bisphenol A (non-halogenated phenol and phenolic compounds) have little effect on T3 sulfation (inhibition at 0.001 mM = 4% and 9%, respectively) | Lithobates catesbeianus | |
pentabromophenol | - |
Lithobates catesbeianus | |
Pentachlorophenol | most potent competitor | Lithobates catesbeianus | |
tetrabromobisphenol A | 52% inhibition at 0.001 mM | Lithobates catesbeianus | |
tetrachlorobisphenol A | 45% inhibition at 0.001 mM | Lithobates catesbeianus | |
tribromophenol | - |
Lithobates catesbeianus | |
trichlorophenol | - |
Lithobates catesbeianus | |
triiodophenol | - |
Lithobates catesbeianus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00022 | - |
3,3',5-triiodothyronine | in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | |
0.00109 | - |
3'-phosphoadenylyl sulfate | in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | |
0.00477 | - |
3,3',5-Triiodothyroacetic acid | in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Lithobates catesbeianus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 3,3',5'-triiodothyronine | Lithobates catesbeianus | best substrate | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,3',5,5'-tetraiodothyroacetic acid | Lithobates catesbeianus | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,3',5-triiodothyroacetic acid | Lithobates catesbeianus | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,3',5-triiodothyronine | Lithobates catesbeianus | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,5-diiodothyronine | Lithobates catesbeianus | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3-iodothyronine | Lithobates catesbeianus | - |
adenosine 3',5'-bisphosphate + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lithobates catesbeianus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Lithobates catesbeianus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 3,3',5'-triiodothyronine | best substrate | Lithobates catesbeianus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,3',5,5'-tetraiodothyroacetic acid | - |
Lithobates catesbeianus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,3',5-triiodothyroacetic acid | - |
Lithobates catesbeianus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,3',5-triiodothyronine | - |
Lithobates catesbeianus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3,5-diiodothyronine | - |
Lithobates catesbeianus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 3-iodothyronine | - |
Lithobates catesbeianus | adenosine 3',5'-bisphosphate + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
iodothyronine sulfotransferase | - |
Lithobates catesbeianus |
SULT | - |
Lithobates catesbeianus |
thyroid hormone sulfotransferase | - |
Lithobates catesbeianus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00015 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | Pentachlorophenol | |
0.00016 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | pentabromophenol | |
0.00021 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | triiodophenol | |
0.00036 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | 2,6-dichlorophenol | |
0.00037 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | trichlorophenol | |
0.00049 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | 2,6-Dichloro-4-nitrophenol | |
0.00055 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | 2,6-dibromophenol | |
0.0008 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | tribromophenol | |
0.00097 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | ioxynil | |
0.00097 | - |
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C | Lithobates catesbeianus | tetrabromobisphenol A |
Organism | Comment | Expression |
---|---|---|
Lithobates catesbeianus | iodothyronine sulfating activity in the liver cytosol is increased in tadpoles at premetamorphic (stages IX-X) and metamorphic climax (stage XX) stages, and in adult frogs | up |