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Literature summary for 2.8.2.2 extracted from

  • Allali-Hassani, A.; Pan, P.W.; Dombrovski, L.; Najmanovich, R.; Tempel, W.; Dong, A.; Loppnau, P.; Martin, F.; Thonton, J.; Edwards, A.M.; Bochkarev, A.; Plotnikov, A.N.; Vedadi, M.; Arrowsmith, C.H.
    Structural and chemical profiling of the human cytosolic sulfotransferases (2007), PLoS Biol., 5, 1063-1078.
No PubMed abstract available
Search for more literature for 2.8.2.2

Crystallization (Commentary)

Crystallization (Comment) Organism
purified SULT1B1 is crystallized in the presence of 2 mM PAP using the hanging drop method at 20°C by mixing for SULT1B1: 0.002 ml of the protein solution with 0.002 ml of the reservoir solution containing 0.1 M Bis-Tris, pH 6.5, 0.2 M ammonium sulfate and 16%-20% PEG 4000 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide DBHM Homo sapiens
3,5-dibromo-4-hydroxybenzoic acid (6,8-dichloro-4-oxo-4H-chromen-3-ylmethylene) hydrazide DBHD Homo sapiens
adenosine 5'-(beta,gamma-imido) triphosphate i.e. AMP-PNP, a non-hydrolysable ATP analogue Homo sapiens
additional information isoprenaline is poor inhibitor of SULT1B1 Homo sapiens
pyridoxal 5'-phosphate a competitive inhibitor for sulfotransferases Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00204
-
-

Reaction

Reaction Comment Organism Reaction ID
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate random bi-bi mechanism catalytic mechanism of SULTs, many family members have distinct, but overlapping substrate specificities, the enzymes have a sequential catalytic mechanism that is susceptible to substrate inhibition Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 1-naphthol SULT1B1 Homo sapiens adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
 ?
additional information SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview Homo sapiens ?
-
 ?
additional information role for 3'-phosphoadenylyl sulfate in priming the conformation of substrate binding loops, overview, substrate specificity and binding structure of SULT1B1, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More detailed structural analysis and comparison of SULT family enzymes, comparison of substrate binding structures of SULT1B1, overview, chemical library preparation and ligand binding screens Homo sapiens

Synonyms

Synonyms Comment Organism
cytosolic sulfotransferase
-
 Homo sapiens
SULT
-
 Homo sapiens
SULT1B1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens