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Literature summary for 2.8.2.2 extracted from

  • Sheng, J.J.; Duffel, M.W.
    Enantioselectivity of human hydroxysteroid sulfotransferase ST2A3 with naphthyl-1-ethanols (2003), Drug Metab. Dispos., 31, 697-700.
    View publication on PubMed
Search for more literature for 2.8.2.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
cloned and expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-(-)-1-naphthyl-1-ethanol inhibitor of the sulfation of dehydroepiandrosterone Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.24
-
 R-(+)-1-naphthyl-1-ethanol pH 7.0, 37°C Homo sapiens
0.25
-
 R-(+)-2-naphthyl-1-ethanol pH 7.0, 37°C Homo sapiens
0.54
-
 S-(-)-2-naphthyl-1-ethanol pH 7.0, 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
67200
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Homo sapiens
-
 human, hDHEA-ST, ST2A3, SULT2A1, PDB code 1EFH
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + R-(+)-1-naphthyl-1-ethanol S-(-)-enantiomer is not a substrate for the enzyme Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylylsulfate + R-(+)-2-naphthyl-1-ethanol both enantiomers are substrates for the enzyme Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylylsulfate + S-(-)-2-naphthyl-1-ethanol both enantiomers are substrates for the enzyme Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?