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Literature summary for 2.8.2.1 extracted from
- Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation (2006), Mol. Pharmacol., 69, 2084-2092.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genetic polymorphisms in the SULT1A1 gene define three alleles, SULT1A1*1, *2, and *3, stable expression of the allozymes in MCF-7 cells, allele-specific antiestrogenic response to 4-hydroxytamoxifen, expression of His-tagged SULT1A1*1, *2, and *3 in Spodoptera frugiperda Sf9 cells via liposome transfection | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| the recombinant SULT1A1*2 protein has a shorter half-life than the recombinant SULT1A1*1 protein | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | substrate inhibition of allozymes SULT1A1*1, *2 and *3 is observed for most substrates | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 4-nitrophenol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? |  |
| additional information | Homo sapiens | SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and 4-nitrophenol | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged SULT1A1*1, *2, and *3 from Spodoptera frugiperda Sf9 cells by metal affinity chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + 2-methoxyestradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen | - |
? | |
| 3'-phosphoadenylyl sulfate + 4-nitrophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
| additional information | SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and 4-nitrophenol | Homo sapiens | ? | - |
? | |
| additional information | substrate specifiicty of SULT1A1*1, *2, and *3, allozyme activities against catecholestrogens and dietary flavonoids, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sulfotransferase 1A1 | - |
Homo sapiens |
| SULT1A1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Homo sapiens |
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