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Literature summary for 2.8.2.1 extracted from

  • Yasuda, S.; Liu, M.Y.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
    Hydroxylated serotonin and dopamine as substrates and inhibitors for human cytosolic SULT1A3 (2007), J. Neurochem., 103, 2679-2689.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information downregulation of SULT1A3 by siRNA in SK-N-MC cells abolishes the formation of 7-hydroxyserotonin and 6-hydroxydopamine Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-Hydroxydopamine competiitve versus dopamine, complete inhibition at about 1 mM Homo sapiens
7-hydroxyserotonin competitive versus serotonin, complete inhibition at about 1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics, SULT1A3 Homo sapiens
0.007
-
dopamine pH 7.0, 37°C, SULT1A3 Homo sapiens
0.019
-
6-Hydroxydopamine pH 7.0, 37°C, SULT1A3 Homo sapiens
0.04
-
7-hydroxyserotonin pH 7.0, 37°C, SULT1A3 Homo sapiens
0.133
-
serotonin pH 7.0, 37°C, SULT1A3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 6-hydroxydopamine Homo sapiens SULT1A3 adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + 7-hydroxyserotonin Homo sapiens SULT1A3 adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + dopamine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + serotonin Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
additional information Homo sapiens the enzyme plays an important role in the regulation and homeostasis of monoamine neurotransmitters, by serving as substrates for SULT1A3, 7-hydroxyserotonin or 6-hydroxydopamine may interfere with the homeostasis of endogenous serotonin and dopamine ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P0DMM9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
Homo sapiens
-
SK-N-MC cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 6-hydroxydopamine SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + 6-hydroxydopamine specific substrate of SULT1A3, no activity with other SULT isozymes Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + 7-hydroxyserotonin SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + 7-hydroxyserotonin specific substrate of SULT1A3, no activity with other SULT isozymes Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + dopamine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + serotonin
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
additional information the enzyme plays an important role in the regulation and homeostasis of monoamine neurotransmitters, by serving as substrates for SULT1A3, 7-hydroxyserotonin or 6-hydroxydopamine may interfere with the homeostasis of endogenous serotonin and dopamine Homo sapiens ?
-
?
additional information DOPA and 6-hydroxy-DOPA are poor substrates for SULT1A3 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cytosolic sulfotransferase
-
Homo sapiens
SULT1A3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
with substrate 7-hydroxyserotonin Homo sapiens
8 9 with substrates dopamine and 6-hydroxydopamine Homo sapiens
11
-
with substrate serotonin Homo sapiens