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Literature summary for 2.8.2.1 extracted from

  • Meinl, W.; Pabel, U.; Osterloh-Quiroz, M.; Hengstler, J.G.; Glatt, H.
    Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue (2006), Int. J. Cancer, 118, 1090-1097.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of SULTs in Escherichia coli strain BL21 DE3, in Salmonella typhimurium strain TA1538, and in chinese hamster V79 cells, and application of aristolochic acid, mutagenicity with expression of different SULT isozymes and allozymes of SULT1A1, detailed overview, analysis of the expression of SULT1A1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Pentachlorophenol inhibits SULT1A1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + aristolochic acid Homo sapiens herbal preparations containing Aristolochia species lead to progressive nephropathy and urothelial cancer in humans, metabolic activation of aristolichic acid, mutagenic effect, overview adenosine 3',5'-bisphosphate + ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P50225 SULT1A1; SULT1A1
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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Homo sapiens
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liver
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + aristolochic acid herbal preparations containing Aristolochia species lead to progressive nephropathy and urothelial cancer in humans, metabolic activation of aristolichic acid, mutagenic effect, overview Homo sapiens adenosine 3',5'-bisphosphate + ?
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?
3'-phosphoadenylyl sulfate + aristolochic acid in renal target tissue, good substrate of SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
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?

Synonyms

Synonyms Comment Organism
sulphotransferase
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Homo sapiens
SULT1A1
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Homo sapiens