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Literature summary for 2.8.2.1 extracted from

  • Hempel, N.; Gamage, N.; Martin, J.L.; McManus, M.E.
    Human cytosolic sulfotransferase SULT1A1 (2007), Int. J. Biochem. Cell Biol., 39, 685-689.
    View publication on PubMed
Search for more literature for 2.8.2.1

Crystallization (Commentary)

Crystallization (Comment) Organism
SULT1A1 complexed with 3'-phosphoadenosine-5'-phosphate and two molecules of 4-nitrophenol, X-ray diffraction structure analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genotyping of the SULT1A1*1/SULT1A1*2 polymorphism, high frequency in the population with potential consequence on the sulfonation of drugs and carcinogens, and in breast and esophageal cancers, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol SULT1A1 Homo sapiens 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens SULT1A1 is a phase II metabolism enzyme responsible for xenobiotic sulfonation, substrate specificity and catalytic function, including its role in the sulfonation of endogenous substrates such as oestrogens from crystal structure, overview, SULT1A1 can also bioactivate compounds, e.g. sulfonate pro-carcinogens such as hydroxymethyl polycyclic aromatic hydrocarbons leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis, roles of allelic variants, regulation of expression and activities, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P50225 allelic variants of SULT1A1
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Source Tissue

Source Tissue Comment Organism Textmining
additional information wide tissue expression of SULT1A1 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 4-nitrophenol
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 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
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 ?
additional information SULT1A1 is a phase II metabolism enzyme responsible for xenobiotic sulfonation, substrate specificity and catalytic function, including its role in the sulfonation of endogenous substrates such as oestrogens from crystal structure, overview, SULT1A1 can also bioactivate compounds, e.g. sulfonate pro-carcinogens such as hydroxymethyl polycyclic aromatic hydrocarbons leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis, roles of allelic variants, regulation of expression and activities, overview Homo sapiens ?
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Synonyms

Synonyms Comment Organism
SULT1A1
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 Homo sapiens