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Literature summary for 2.8.2.1 extracted from

  • Ohtake, E.; Kakihara, F.; Matsumoto, N.; Ozawa, S.; Ohno, Y.; Hasegawa, S.; Suzuki, H.; Kubota, T.
    Frequency distribution of phenol sulfotransferase 1A1 activity in platelet cells from healthy Japanese subjects (2006), Eur. J. Pharm. Sci., 28, 272-277.
    View publication on PubMed
Search for more literature for 2.8.2.1

Cloned(Commentary)

Cloned (Comment) Organism
SULT1A1, DNA and amino acid sequence determination and analysis, sequence determination and distribution analysis of mutations other than SULT1A1*2 in the SULT1A1 gene, overview, expression of SULT1A1*1 and SULT1A1*2 allozymes Homo sapiens

Protein Variants

Protein Variants Comment Organism
G148C naturally occuring mutation of the SULt1A1 gene, frequency is 0.49% in the Japanese population, the mutant shows reduced enzyme activity with substrate trans-4-hydroxytamoxifen compared to the wild-type enzyme Homo sapiens
additional information sequence determination and distribution analysis of mutations other than SULT1A1*2 in the SULT1A1 gene, SULT1A1*2 allele frequency is 16.5% in the Japanese population, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50225 Japanese individuals possessing the polymorphic SULT1A1*2 allele
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Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
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 Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activities of SULT1A1*1 and SULT1A1*2 allozymes with trans-4-hydroxytamoxifen, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + trans-4-hydroxytamoxifen substrate of the allozymes SULT1A1*2 and SULT1A1*1 Homo sapiens adenosine 3',5'-bisphosphate + trans-4-(sulfooxy)tamoxifen
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 ?

Synonyms

Synonyms Comment Organism
phenol sulfotransferase
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 Homo sapiens
SULT1A1
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 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 assay at Homo sapiens