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Literature summary for 2.8.2.1 extracted from

  • Ung, D.; Nagar, S.
    Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1 (2007), Drug Metab. Dispos., 35, 740-746.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the human SULT1A1 gene has common single nucleotide polymorphisms that define three allozymes, SULT1A1*1, *2, and *3, stable expression of the allozymes in MCF-7 cells and expression of His-tagged SULT1A1 allozymes using a baculoviral-Spodoptera frugiperda Sf9 cell system Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of SULT1A1 allozymes, overview Homo sapiens
0.0005
-
resveratrol pH 6.5, 37°C, allozyme SULT1A1*2 Homo sapiens
0.0011
-
resveratrol pH 6.5, 37°C, allozyme SULT1A1*3 Homo sapiens
0.00172
-
apigenin pH 6.5, 37°C, allozyme SULT1A1*1 Homo sapiens
0.0023
-
resveratrol pH 6.5, 37°C, allozyme SULT1A1*1 Homo sapiens
0.0025
-
chrysin pH 6.5, 37°C, allozyme SULT1A1*1 Homo sapiens
0.00257
-
apigenin pH 6.5, 37°C, allozyme SULT1A1*3 Homo sapiens
0.00264
-
apigenin pH 6.5, 37°C, allozyme SULT1A1*2 Homo sapiens
0.0351
-
quercetin pH 6.5, 37°C, allozyme SULT1A1*1 Homo sapiens
0.065
-
epicatechin pH 6.5, 37°C, allozyme SULT1A1*3 Homo sapiens
0.242
-
epicatechin pH 6.5, 37°C, allozyme SULT1A1*1 Homo sapiens
0.419
-
epicatechin pH 6.5, 37°C, allozyme SULT1A1*2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50225 SULT1A1
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
substrate specificity of the three allozymes SULT1A1*1, *2, and *3, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + apigenin
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + chrysin substrate of allozyme SULT1A1*1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + epicatechin
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + quercetin allozyme SULT1A1*1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylyl sulfate + resveratrol
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
additional information SULT1A1 catalyzes the sulfation of small planar phenolic compounds, substrate specificity of the three allozymes SULT1A1*1, *2, and *3, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
SULT1A1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Homo sapiens