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Literature summary for 2.8.2.1 extracted from

  • Nishimuta, H.; Tsujimoto, M.; Ogura, K.; Hiratsuka, A.; Ohtani, H.; Sawada, Y.
    Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 (2005), Pharm. Res., 22, 1406-1410.
    View publication on PubMed
Search for more literature for 2.8.2.1

Application

Application Comment Organism
medicine concomitant ingestion of beverages such as green tea and black tea may increase the bioavailability of orally administered ritodrine, and perhaps other beta-agonists Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, enzyme form SULT1A3 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme form SULT1A1 is significantly inhibited by all beverages examined (grapefruit juice, orange juice, green tea and black tea) at a concentration of 10%. Green tea and black tea exhibit potent inhibition, even at a concentration of 5%, they both inhibit SULT1A1 by 100%; enzyme form SULT1A3 is significantly inhibited by all beverages examined (grapefruit juice, orange juice, green tea and black tea) at a concentration of 10%. Green tea and black tea exhibit potent inhibition, even at a concentration of 5%, they both inhibit SULT1A3 by more than 95% Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.438
-
 ritodrine enzyme form SULT1A3 Homo sapiens
3.08
-
 ritodrine enzyme form SULT1A1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 enzyme form SULT1A1
-
Homo sapiens
-
 enzyme form SULT1A3
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme, enzyme form SULT1A3 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestinal mucosa enzyme form SULT1A1 Homo sapiens
-
intestinal mucosa enzyme form SULT1A3 Homo sapiens
-
liver enzyme form SULT1A1 Homo sapiens
-
liver enzyme form SULT1A3 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + ritodrine enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ritodrine sulfate
-
 ?
3'-phosphoadenylylsulfate + ritodrine enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ritodrine sulfate
-
 ?

Synonyms

Synonyms Comment Organism
SULT1A1
-
 Homo sapiens
SULT1A3
-
 Homo sapiens