Literature summary for 2.8.2.1 extracted from

Yeh, C.T.; Huang, S.M.; Yen, G.C.
Induction of phenolsulfotransferase expression by phenolic acids in human hepatoma HepG2 cells (2005), J. Agric. Food Chem., 53, 4766-4773.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	phenolsulfotransferase is a key enzyme in drug metabolism, bile acid detoxification, and the regulation of intratissue active hormone levels. The increased gene expression of phenolsulfotransferase promotes the efficiency of detoxification. Certain antioxidant phenolic acids could induce PST-P activity in HepG2 cells, by promoting PST-P mRNA and protein expression, suggesting a novel mechanism by which phenolic acids may be implicated in phase II sulfate conjugation. Gallic acid, gentisic acid, p-hydroxybenzoic acid, and p-coumaric acid increase PST-P activity, in a dose-dependent manner. A maximum of 4fold and 5fold induction of PST-P activity is observed for both gallic acid and gentisic acid, adverse effect on cell growth at higher concentrations. A 2fold or 2.5fold increase of PST-P activity is found with either p-coumaric or p-hydroxybenzoic acid treatment, no significant effect is found for ferulic acid treatment	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50225	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	phenolsulfotransferase is a key enzyme in drug metabolism, bile acid detoxification, and the regulation of intratissue active hormone levels. The increased gene expression of phenolsulfotransferase promotes the efficiency of detoxification. Certain antioxidant phenolic acids could induce PST-P activity in HepG2 cells, by promoting PST-P mRNA and protein expression, suggesting a novel mechanism by which phenolic acids may be implicated in phase II sulfate conjugation. Gallic acid, gentisic acid, p-hydroxybenzoic acid, and p-coumaric acid increase PST-P activity, in a dose-dependent manner. A maximum of 4fold and 5fold induction of PST-P activity is observed for both gallic acid and gentisic acid, adverse effect on cell growth at higher concentrations. A 2fold or 2.5fold increase of PST-P activity is found with either p-coumaric or p-hydroxybenzoic acid treatment, no significant effect is found for ferulic acid treatment	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)