Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Co2+ | P-PST, not M-PST; P-PST, slightly inhibiting with minoxidil as substrate | Homo sapiens | |
Cu2+ | M-PST and P-PST, strong inhibition | Homo sapiens | |
Fe2+ | M-PST, not P-PST | Homo sapiens | |
Hg2+ | M-PST and P-PST, strong inhibition | Homo sapiens | |
additional information | influence of divalent metal ions, overview | Homo sapiens | |
Zn2+ | P-PST and M-PST | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
dobutamine | M-PST, pH 7.0, 37°C | Homo sapiens | |
0.2 | - |
minoxidil | P-PST, pH 7.0, 37°C | Homo sapiens | |
0.43 | - |
acetaminophen | M-PST, pH 7.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | M-PST | Homo sapiens | 5829 | - |
cytosol | P-PST | Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | P-PST, slightly stimulating with acetaminophen as substrate | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + a phenol | Homo sapiens | phase II drug metabolizing or detoxifying enzyme | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + a phenol | Homo sapiens | sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity of P-PST and M-PST with drug compounds as substrates, overview | Homo sapiens |
0.106 | - |
M-PST, substrate dobutamine | Homo sapiens |
0.147 | - |
P-PST, substrate (+/-)isoproterenol | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + a phenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + (+/-)isoproterenol | P-PST and M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + (+/-)metoprolol | P-PST, not M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + (+/-)salbutamol | P-PST and M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + (+/-)sotalol | P-PST, not M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + 4-methylumbelliferone | P-PST and M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + a phenol | phase II drug metabolizing or detoxifying enzyme | Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + a phenol | sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds | Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + acebutolol | P-PST, not M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + acetaminophen | M-PST and P-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + bupivacaine | P-PST, not M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + dexamethasone | P-PST, not M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + DL-propanolol | P-PST, not M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + dobutamine | P-PST and M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + lidocaine | P-PST and M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + minoxidil | M-PST | Homo sapiens | adenosine 3',5'-bisphosphate + minoxidil sulfate | - |
? | |
3'-phosphoadenylylsulfate + minoxidil | P-PST | Homo sapiens | adenosine 3',5'-bisphosphate + minoxidil sulfate | - |
? | |
additional information | substrate specificity | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |