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Literature summary for 2.8.2.1 extracted from

  • Falany, C.N.; Zhuang, W.; Falany, J.L.
    Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability (1994), Chem. Biol. Interact., 92, 57-66.
    View publication on PubMed
Search for more literature for 2.8.2.1

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination, expression of P-PST in COS cells and Escherichia coli XL1-Blue Homo sapiens

Protein Variants

Protein Variants Comment Organism
C70S mutation has no effect on enzymic activity, but the mutant is more thermosensitive than the wild-type Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol P-PST Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + a phenol Homo sapiens sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 2 forms of P-PST: PI-PST and PII-PST, differing in their thermostability
-
Homo sapiens
-
 2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-

Reaction

Reaction Comment Organism Reaction ID
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate Cys70 is not essential for activity Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
liver 2 forms of P-PST: PI-PST and PII-PST, differing in their thermostability Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
3'-phosphoadenylylsulfate + a phenol sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
3'-phosphoadenylylsulfate + dopamine P-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylylsulfate + epinephrine P-PST Homo sapiens adenosine 3',5'-bisphosphate + epinephrine sulfate
-
 ?
3'-phosphoadenylylsulfate + minoxidil P-PST Homo sapiens adenosine 3',5'-bisphosphate + minoxidil sulfate
-
 ?