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Literature summary for 2.8.2.1 extracted from

  • Veronese, M.E.; Burgess, W.; Zhu, X.; McManus, M.E.
    Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies (1994), Biochem. J., 302, 497-502.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of simple phenol sulfating P-PST and monoamine sulfating M-PST in COS-7 cells as HAST1 and HAST3 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,6-Dichloro-4-nitrophenol
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0006
-
4-nitrophenol recombinant isozyme P-PST, i.e. HAST1 Homo sapiens
0.0097
-
dopamine recombinant isozyme M-PST, i.e. HAST3 Homo sapiens
0.345
-
4-nitrophenol recombinant isozyme M-PST, i.e. HAST3 Homo sapiens
2.2
-
dopamine recombinant isozyme P-PST, i.e. HAST1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol
-
Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
3'-phosphoadenylylsulfate + dopamine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
HAST1 is considerably more thermostable than HAST3 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens