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Literature summary for 2.8.2.1 extracted from

  • Weinshilboum, R.M.
    Phenol sulfotransferase in humans: properties, regulation, and function (1986), Fed. Proc., 45, 2223-2228.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,6-Dichloro-4-nitrophenol 2 forms, TL: relatively resistant to inhibition by 2,6-dichloro-4-nitrophenol, TS: relatively sensitive to 2,6-dichloro-4-nitrophenol Homo sapiens
ATP
-
Homo sapiens
additional information no inhibition by normetanephrine, metanephrine, dopamine, the presence of an amino group on the side chain which is positively charged at pH 7.4 drastically decreases inhibitory power, substrate inhibition for most compounds at concentrations exceeding approximately 5times the Km Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no effect: Mg2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
2 forms: thermolabile TL, thermostable TS
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
platelet
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
rapid, simple sensitive radioassay Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol
-
Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol preferred substrate of TS enzyme form Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
3'-phosphoadenylylsulfate + dopamine preferred substrate of TL enzyme form Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
additional information 2 forms, TL: thermolabile, sulfate conjugation of dopamine and other phenolic monoamines, TS: thermostable, sulfate conjugation of simple phenols, e.g. p-nitrophenol Homo sapiens ?
-
?
additional information no activity: serotonin Homo sapiens ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
one thermolabile form TL and one thermostable form TS Homo sapiens