Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-Dichloro-4-nitrophenol | 2 forms, TL: relatively resistant to inhibition by 2,6-dichloro-4-nitrophenol, TS: relatively sensitive to 2,6-dichloro-4-nitrophenol | Homo sapiens | |
ATP | - |
Homo sapiens | |
additional information | no inhibition by normetanephrine, metanephrine, dopamine, the presence of an amino group on the side chain which is positively charged at pH 7.4 drastically decreases inhibitory power, substrate inhibition for most compounds at concentrations exceeding approximately 5times the Km | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no effect: Mg2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
2 forms: thermolabile TL, thermostable TS | - |
Purification (Comment) | Organism |
---|---|
partial | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
platelet | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
rapid, simple sensitive radioassay | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + a phenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + 4-nitrophenol | preferred substrate of TS enzyme form | Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
3'-phosphoadenylylsulfate + dopamine | preferred substrate of TL enzyme form | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
additional information | 2 forms, TL: thermolabile, sulfate conjugation of dopamine and other phenolic monoamines, TS: thermostable, sulfate conjugation of simple phenols, e.g. p-nitrophenol | Homo sapiens | ? | - |
? | |
additional information | no activity: serotonin | Homo sapiens | ? | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
one thermolabile form TL and one thermostable form TS | Homo sapiens |