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Literature summary for 2.8.1.B3 extracted from
- The rhodanese domain of ThiI is both necessary and sufficient for synthesis of the thiazole moiety of thiamine in Salmonella enterica (2011), J. Bacteriol., 193, 4582-4587.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C456S | the mutant is not able to restore growth of a thiI mutant strain in minimal medium suggesting that C456 is required for thiazole synthesis in vivo | Salmonella enterica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmonella enterica | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ThiI | - |
Salmonella enterica |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | ThiI is a bifunctional enzyme required for the synthesis of both the 4-thiouridine modification in tRNA and the thiazole moiety of thiamine. In 4-thiouridine biosynthesis, ThiI adenylates the tRNA uridine and transfers sulfur from a persulfide formed on the protein. The C-terminal rhodanese domain of ThiI is sufficient for thiazole synthesis in vivo | Salmonella enterica |
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