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Literature summary for 2.8.1.8 extracted from
- Destruction and reformation of an iron-sulfur cluster during catalysis by lipoyl synthase (2017), Science, 358, 373-377 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P60716 | - |
- |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| [4Fe-4S]-center | LipA contains two [4Fe-4S] clusters, one of them is degraded during turnover, limiting LipA to one turnover in vitro. The iron-sulfur (Fe-S) cluster carrier protein NfuA, the bacterial ortholog of NFU1, efficiently reconstitutes the auxiliary cluster during LipA catalysis in a step that is not rate-limiting | Escherichia coli |  |
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