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Literature summary for 2.8.1.6 extracted from

  • Fugate, C.J.; Stich, T.A.; Kim, E.G.; Myers, W.K.; Britt, R.D.; Jarrett, J.T.
    9-Mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]+ cluster during the reaction catalyzed by biotin synthase from Escherichia coli (2012), J. Am. Chem. Soc., 134, 9042-9045.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9-mercaptodethiobiotin + [S] + S-adenosyl-L-methionine
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Escherichia coli biotin + L-methionine + 5'-deoxyadenosine
-
ir
dethiobiotin + [S] + S-adenosyl-L-methionine 9-mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]2+ cluster during the reaction Escherichia coli 9-mercaptodethiobiotin + L-methionine + 5'-deoxyadenosine
-
ir
dethiobiotin + [S] + S-adenosyl-L-methionine overall reaction Escherichia coli biotin + L-methionine + 5'-deoxyadenosine
-
ir

Synonyms

Synonyms Comment Organism
BioB
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
Fe-S center the enzyme contains a [2Fe-2S]2+ cluster Escherichia coli