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Literature summary for 2.8.1.6 extracted from

  • Fugate, C.J.; Jarrett, J.T.
    Biotin synthase: insights into radical-mediated carbon-sulfur bond formation (2012), Biochim. Biophys. Acta, 1824, 1213-1222.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
dethiobiotin pH and temperature not specified in the publication Escherichia coli
0.2
-
9-Mercaptodethiobiotin pH and temperature not specified in the publication Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38600
-
2 * 38600, calculated from amino acid sequence Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P12996
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9-mercaptodethiobiotin + [S] + S-adenosyl-L-methionine
-
Escherichia coli biotin + ?
-
?
dethiobiotin + [S] + S-adenosyl-L-methionine dethiobiotin is 5-methyl-2-oxo-4-imidazolidinehexanoic acid Escherichia coli biotin + L-methionine + 5'-deoxyadenosine
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 38600, calculated from amino acid sequence Escherichia coli

Synonyms

Synonyms Comment Organism
BioB
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
Fe-S center the enzyme contains one [4Fe-4S]2+ cluster and one air-stable [2Fe-2S]2+ cluster per monomer Escherichia coli