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Literature summary for 2.8.1.6 extracted from

  • Tse Sum Bui, B.; Mattioli, T.A.; Florentin, D.; Bolbach, G.; Marquet, A.
    Escherichia coli biotin synthase produces selenobiotin. Further evidence of the involvement of the [2Fe-2S]2+ cluster in the sulfur insertion step (2006), Biochemistry, 45, 3824-3834.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Iron the [2Fe-2S]2+ cluster is implicated in the sulfur insertion step Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dethiobiotin + Na2S
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Escherichia coli biotin
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dethiobiotin + Na2Se enzyme depleted of iron and sulfur and reconstituted with FeCl3 and Na2Se yielding an [2Fe-2Se]2+ cluster. Activity with Na2Se is lower than that of the as-isolated enzyme with Na2S Escherichia coli selenobiotin
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additional information enzyme depleted of iron and sulfur and reconstituted with FeCl3 and Na2Se to enable formation an [2Fe-2Se]2+ cluster. The [2Fe-2Se]2+ enzyme yields a mixture of biotin and selenobiotin in presence of Na2S Escherichia coli ?
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