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Literature summary for 2.8.1.6 extracted from

  • Broach, R.B.; Jarrett, J.T.
    Role of the [2Fe-2S]2+ cluster in biotin synthase: mutagenesis of the atypical metal ligand arginine 260 (2006), Biochemistry, 45, 14166-14174.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
R260A contains 1.8 iron atoms per monomer, slightly less active than wild-type Escherichia coli
R260C contains 2.0 iron atoms per monomer, slightly more active than wild-type Escherichia coli
R260H contains 1.3 iron atoms per monomer, slightly less active than wild-type Escherichia coli
R260M contains 1.1 iron atoms per monomer, about 30% of wild-type activity Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Iron [2Fe-2S]2+ cluster coordinated by C97, C128, C188 and R260. Wild-type enzyme contains 1.6 iron atoms per monomer Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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