Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.8.1.6 extracted from

  • Choi-Rhee, E.; Cronan, J.E.
    Biotin synthase is catalytic in vivo, but catalysis engenders destruction of the protein (2005), Chem. Biol., 12, 461-468.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme has very modest catalytic power. 20-60 molecules of biotin are formed per molecule of enzyme, which is easily degraded. Substantial unfolding of enzyme is required to allow rebuilding of the (2Fe-2S) cluster after each turnover. Such unfolding allows restoration of the cluster, but at the cost of exposure of the protein to proteolytic attack Escherichia coli ?
-
?