Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibitory: pyridoxal 5-phosphate, deoxyadenosine | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin | reaction proceeds via intermediate involving the (2Fe-2S) cluster, with a rate-determining step following the formation of this intermediate | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
9-mercaptodethiobiotin + S-adenosyl-L-methionine | presence of S-adenosyl-L-methionine is required | Escherichia coli | biotin + ? | - |
? | |
dethiobiotin + sulfur | - |
Escherichia coli | biotin | - |
? | |
additional information | reaction has a turnover of one. Enzyme has no cysteine desulfurase activity, the required sulfide has to be added as Na2S. The active enzyme cannot be fully restored after one turn | Escherichia coli | ? | - |
? |