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Literature summary for 2.8.1.6 extracted from

  • Ollagnier-de-Choudens, S.; Mulliez, E.; Fontecave, M.
    The PLP-dependent biotin synthase from Escherichia coli: mechanistic studies (2002), FEBS Lett., 532, 465-468.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
S-adenosyl-L-methionine one molecule S-adenosyl-L-methionine is required to form one molecule of biotin Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5'-deoxyadenosine strong inhibitor, reversible, 90% inhibition upon addition of 1 equivalent of 5'-deoxyadenosine with regard to the enzyme Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Iron the enzyme contains an iron-sulfur cluster Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dethiobiotin + sulfur Escherichia coli catalyzes the last step of the biosynthesis of biotin biotin
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dethiobiotin + sulfur
-
Escherichia coli biotin
-
?
dethiobiotin + sulfur catalyzes the last step of the biosynthesis of biotin Escherichia coli biotin
-
?