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Literature summary for 2.8.1.6 extracted from

  • Berkovitch, F.; Nicolet, Y.; Wan, J.T.; Jarrett, J.T.; Drennan, C.L.
    Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme (2004), Science, 303, 76-79.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
complexed with S-adenosyl-L-methionine and dethiobiotin Escherichia coli
in complex with S-adensyl-L-methionine and dethiobiotin Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Iron [2Fe-2S] and [4Fe-4S] cluster Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P12996
-
-

Reaction

Reaction Comment Organism Reaction ID
dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin substrates are placed between the (4Fe-4S) cluster, essential for radical generation, and the (2Fe-2S) cluster Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dethiobiotin + sulfur
-
Escherichia coli biotin
-
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