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Literature summary for 2.8.1.6 extracted from

  • Ugulava, N.B.; Sacanell, C.J.; Jarrett, J.T.
    Spectroscopic changes during a single turnover of biotin synthase: Destruction of a [2Fe-2S] cluster accompanies sulfur insertion (2001), Biochemistry, 40, 8352-8358.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.1.6

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol
-
 Escherichia coli
flavodoxin reductase omission results in a 100fold decrease in activity Escherichia coli
S-adenosyl-L-methionine required Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
FeCl3
-
 Escherichia coli
Iron 1 [2Fe-2S] and 1 [4Fe-4S] cluster per monomer are essential for optimal activity Escherichia coli
Na2S
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38400
-
 2 * 38400 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dethiobiotin + sulfur insertion of a sulfur atom between the saturated C6 and C9 carbons of dethiobiotin Escherichia coli biotin
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 38400 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
flavodoxin required Escherichia coli
NADPH omission results in a 100fold decrease in activity Escherichia coli