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Literature summary for 2.8.1.6 extracted from

  • Shaw, N.M.; Birch, O.M.; Tinschert, A.; Venetz, V.; Dietrich, R.; Savoy, L.A.
    Biotin synthase from Escherichia coli: isolation of an enzyme-generated intermediate and stoichiometry of S-adenosylmethionine use (1998), Biochem. J., 330, 1079-1085.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
asparagine required Escherichia coli
L-cysteine required Escherichia coli
S-adenosyl-L-methionine two molecules of S-adenosyl-L-methionine are used to synthesize one molecule of biotin, one from dethiobiotin to the intermediate, and a second from the intermediate to biotin Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dethiobiotin + sulfur
-
Escherichia coli biotin
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5
-
Escherichia coli