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Literature summary for 2.8.1.6 extracted from

  • Bui, B.T.S.; Florentin, D.; Fournier, F.; Ploux, O.; Mejean, A.; Marquet, A.
    Biotin synthase mechanism: on the origin of sulfur (1998), FEBS Lett., 440, 226-230.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
FeCl3
-
Escherichia coli
FeCl3 enhances activity 3-4fold at 0.1 mM Lysinibacillus sphaericus
Iron the enzyme contains an iron-sulfur cluster Escherichia coli
Iron the enzyme contains an iron-sulfur cluster Lysinibacillus sphaericus
Na2S
-
Escherichia coli
Na2S enhances activity 3-4fold at 1 mM Lysinibacillus sphaericus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dethiobiotin + sulfur Escherichia coli hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme biotin
-
?
dethiobiotin + sulfur Lysinibacillus sphaericus hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme biotin
-
?
dethiobiotin + sulfur Escherichia coli catalyzes the last step of the biosynthesis of biotin biotin
-
?
dethiobiotin + sulfur Lysinibacillus sphaericus catalyzes the last step of the biosynthesis of biotin biotin
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Lysinibacillus sphaericus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin mechanism Escherichia coli
dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin mechanism Lysinibacillus sphaericus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dethiobiotin + sulfur
-
Escherichia coli biotin
-
?
dethiobiotin + sulfur
-
Lysinibacillus sphaericus biotin
-
?
dethiobiotin + sulfur hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme Escherichia coli biotin
-
?
dethiobiotin + sulfur hypothesis: sulfur of biotin is derived from the [Fe-S] center of the enzyme Lysinibacillus sphaericus biotin
-
?
dethiobiotin + sulfur catalyzes the last step of the biosynthesis of biotin Escherichia coli biotin
-
?
dethiobiotin + sulfur catalyzes the last step of the biosynthesis of biotin Lysinibacillus sphaericus biotin
-
?