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Literature summary for 2.8.1.6 extracted from
- Biotin synthase from Escherichia coli, an investigation of the low molecular weight and protein components required for activity in vitro (1995), J. Biol. Chem., 270, 19158-19165.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| amino acid | one of the amino acids: Asn, Asp, Gln or Ser | Escherichia coli |  |
| L-cysteine | required as sulfur donor | Escherichia coli | |
| Pyridine nucleotide | required, NADPH being most effective | Escherichia coli | |
| S-adenosyl-L-methionine | required | Escherichia coli | |
| thiamine diphosphate-dependent protein | required | Escherichia coli |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | required | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dethiobiotin + sulfur | - |
Escherichia coli | biotin | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Ferredoxin | required | Escherichia coli | |
| flavodoxin | required | Escherichia coli | |
| thiamine diphosphate | required | Escherichia coli | |
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