Protein Variants | Comment | Organism |
---|---|---|
C247S | inactive | Mus musculus |
R187G | inactive | Mus musculus |
R196G | the mutant shows reduced H2S-producing activity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sulfite | H2S production by the enzyme is suppressed by sulfite | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-mercaptopyruvate + thiosulfate | - |
Mus musculus | pyruvate + H2S | - |
? | |
additional information | the enzyme produces hydrogen sulfide in the presence of both cysteine and 2-oxoglutarate. Thioredoxin and dihydrolipoic acid associate with 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide. Other reducing substances, such as NADPH, NADH, GSH, cysteine and CoA, do not have any effect on the reaction | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3MST | - |
Mus musculus |