Literature summary for 2.7.8.33 extracted from

Yan, K.; Liu, T.; Duan, B.; Liu, F.; Cao, M.; Peng, W.; Dai, Q.; Chen, H.; Yuan, F.; Bei, W.
The CpxAR two-component system contributes to growth, stress resistance, and virulence of Actinobacillus pleuropneumoniae by upregulating wecA transcription (2020), Front. Microbiol., 11, 1026 .

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Organism

Organism	UniProt	Comment	Textmining
Actinobacillus pleuropneumoniae serotype 5b L20	A3N2K2	-	-

Synonyms

Synonyms	Comment	Organism
WecA	-	Actinobacillus pleuropneumoniae serotype 5b L20

Expression

Organism	Comment	Expression
Actinobacillus pleuropneumoniae serotype 5b L20	CpxR positively regulates WecA expression by directly binding to the putative promoter region of WecA	up

General Information

General Information	Comment	Organism
physiological function	strains lacking transcription regulator component CpxAR or WecA are more susceptible to these stresses than the wild-type, but the complemented strains show phenotypes similar to those of the wild-type. Mice infected with strains lacking CpxAR or WecA activity exhibit lower mortality and bacterial loads in the lung than those infected with the wild-type or complemented strains	Actinobacillus pleuropneumoniae serotype 5b L20

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Release 2023.1 (January 2023)