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Literature summary for 2.7.8.15 extracted from

  • Dan, N.; Lehrman, M.A.
    Oligomerization of hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase, an enzyme with multiple transmembrane spans (1997), J. Biol. Chem., 272, 14214-14219.
    View publication on PubMed
Search for more literature for 2.7.8.15

Protein Variants

Protein Variants Comment Organism
R303K catalytically inactive mutant enzyme, this mutant can be expressed in CHO-K1 cells and can bind tunicamycin efficiently, indicative of proper folding. The R303K mutant can inhibit exogenously expressed normal enzyme Cricetulus griseus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum an enzyme with multiple transmembrane spans Cricetulus griseus 5783
-
membrane enzyme with multiple transmembrane spans Cricetulus griseus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 2 * 34000, the 67000 Da enzyme form is a homodimer of UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase or perhaps a hetero-oligomer with another microsomal component Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Cricetulus griseus UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 34000, the 67000 Da enzyme form is a homodimer of UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase or perhaps a hetero-oligomer with another microsomal component Cricetulus griseus