Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.15 extracted from

  • Mota, O.M.; Huang, G.T.; Kukuruzinska, M.A.
    Developmental regulation and tissue-specific expression of hamster dolichol-P-dependent N-acetylglucosamine-1-P transferase (GPT) (1994), Biochem. Biophys. Res. Commun., 204, 284-291.
    View publication on PubMed
Search for more literature for 2.7.8.15

Protein Variants

Protein Variants Comment Organism
A263D mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
D252A mutation does not allow plasmid shuffling, indicating that the residues is essential for activity Cricetulus griseus
D252A/F254I mutation does not allow plasmid shuffling, indicating that the residues are essential for activity Cricetulus griseus
D252A/L102F mutation does not allow plasmid shuffling, indicating that the residues are essential for activity Cricetulus griseus
F249A mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
F257A mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
K125A mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
N182A mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
N182A/I186M mutation does not allow plasmid shuffling, indicating that the residues are essential for activity Cricetulus griseus
N182A/W122R mutation does not allow plasmid shuffling, indicating that the residues are essential for activity Cricetulus griseus
N185A mutation does not allow plasmid shuffling, indicating that the residue is essential for activity Cricetulus griseus
R123A mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
W122R mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
Y256A mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus
Y256A/F286S mutation allows plasmid shuffling, indicating that the residue is not essential for activity Cricetulus griseus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 ALG7 1.5 kb mRNAs appears to be initiated at a start site downstream from that used by the 1.9 and 2.2 kb species and located bentween two in-frame ATG codons. Translation of these transcripts in vitro provides supporting evidence that the 1.5 and 1.9 kb transcripts are translationally competent, giving rise to related protein isoforms with different lengths of their NH2-terminal domains. The 1.9 kb mRNA serves in the synthesis of 36000 Da and 24000 Da species, as well as a low abundance 32000 Da protein. The 1.5 kb transcript gives rise to a translation product of 32000 Da Cricetulus griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + dolichyl phosphate Cricetulus griseus the enzyme is encoded by ALG7, whose expression affects the extent of N-glycosylation and secretion of proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Cricetulus griseus
-
CHO cell
-
 Cricetulus griseus
-
heart
-
 Cricetulus griseus
-
kidney
-
 Cricetulus griseus
-
lung
-
 Cricetulus griseus
-
spleen
-
 Cricetulus griseus
-
submandibular gland
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Cricetulus griseus UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate the enzyme is encoded by ALG7, whose expression affects the extent of N-glycosylation and secretion of proteins Cricetulus griseus ?
-
 ?