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Literature summary for 2.7.8.11 extracted from

  • Morii, H.; Ogawa, M.; Fukuda, K.; Taniguchi, H.
    Ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in bacteria and archaea, which contain inositol phospholipid (2013), Biochem. Biophys. Res. Commun., 443, 86-90.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Homo sapiens cells. The recombinant cells do not show phosphatidylinositol phosphate synthase or archaetidylinositol phosphate synthase activities. Phosphatidylinositol synthase and archaetidylinositol synthase activities are determined, 7 pmol/h/mg and 2 pmol/h/mg, respectively Homo sapiens
additional information an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Saccharomyces cerevisiae cells. The recombinant cells do not show phosphatidylinositol phosphate synthase or archaetidylinositol phosphate synthase activities. Phosphatidylinositol synthase and archaetidylinositol synthase activities are determined, 107 pmol/h/mg and 7 pmol/h/mg, respectively Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Homo sapiens
Mn2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + myo-inositol Homo sapiens
-
CMP + 1-phosphatidyl-1D-myo-inositol
-
?
CDP-diacylglycerol + myo-inositol Saccharomyces cerevisiae
-
CMP + 1-phosphatidyl-1D-myo-inositol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae P70500
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + myo-inositol
-
Homo sapiens CMP + 1-phosphatidyl-1D-myo-inositol
-
?
CDP-diacylglycerol + myo-inositol
-
Saccharomyces cerevisiae CMP + 1-phosphatidyl-1D-myo-inositol
-
?
CDP-diacylglycerol + myo-inositol specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate Homo sapiens CMP + 1-phosphatidyl-1D-myo-inositol
-
?
CDP-diacylglycerol + myo-inositol specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate Saccharomyces cerevisiae CMP + 1-phosphatidyl-1D-myo-inositol
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol synthase
-
Homo sapiens
phosphatidylinositol synthase
-
Saccharomyces cerevisiae
PI synthase
-
Homo sapiens
PI synthase
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Saccharomyces cerevisiae
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens
8
-
assay at Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism in eukarya, phosphatidylinositol (PI) is only biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol Homo sapiens
metabolism in eukarya, phosphatidylinositol (PI) is only biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol Saccharomyces cerevisiae