Cloned (Comment) | Organism |
---|---|
cDNA cloned by functional complementation of a Saccharomyces cerevisiae mutant | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Bos taurus | |
Ca2+ | - |
Cavia porcellus | |
Ca2+ | - |
Homo sapiens | |
Ca2+ | - |
Oryctolagus cuniculus | |
Ca2+ | - |
Rattus norvegicus | |
CDP-diacylglycerol | above 0.5 mM | Homo sapiens | |
CDP-diacylglycerol | above 0.4 mM | Rattus norvegicus | |
diphosphate | - |
Homo sapiens | |
hexachlorocyclohexane | inhibition is non-competitive and not specific for inositol processing enzymes | Homo sapiens | |
additional information | AMP CMP, GMP, UMP, TMP, TDP, and GDP are not inhibitory, triphosphates are even more inhibitory than diphosphates; no inhibition with 2-deoxy-CDP-diacylglycerol | Homo sapiens | |
phosphate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0095 | - |
CDP-diacylglycerol | - |
Rattus norvegicus | |
0.036 | - |
CDP-diacylglycerol | - |
Homo sapiens | |
0.045 | - |
2-deoxy-CDP-diacylglycerol | - |
Homo sapiens | |
0.28 | - |
myo-inositol | - |
Homo sapiens | |
1.3 | - |
myo-inositol | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Oryctolagus cuniculus | 5783 | - |
endoplasmic reticulum | localized to both the rough and the smooth endoplasmic reticulum | Rattus norvegicus | 5783 | - |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
membrane | - |
Gallus gallus | 16020 | - |
membrane | - |
Cavia porcellus | 16020 | - |
membrane | membrane-bound | Homo sapiens | 16020 | - |
membrane | membrane-bound | Rattus norvegicus | 16020 | - |
membrane | membrane-bound | Saccharomyces cerevisiae | 16020 | - |
microsome | - |
Cavia porcellus | - |
- |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Saccharomyces cerevisiae | - |
- |
microsome | - |
Bos taurus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
plasma membrane | proximal tubule cells | Oryctolagus cuniculus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Cavia porcellus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Saccharomyces cerevisiae | |
Mg2+ | - |
Bos taurus | |
Mg2+ | - |
Oryctolagus cuniculus | |
Mn2+ | - |
Cavia porcellus | |
Mn2+ | - |
Homo sapiens | |
Mn2+ | - |
Rattus norvegicus | |
Mn2+ | - |
Saccharomyces cerevisiae | |
Mn2+ | - |
Bos taurus | |
Mn2+ | - |
Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21000 | - |
? * 21000, SDS-PAGE | Rattus norvegicus |
23610 | - |
- |
Rattus norvegicus |
24000 | - |
SDS-PAGE | Homo sapiens |
34000 | - |
- |
Rattus norvegicus |
34000 | - |
- |
Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-diacylglycerol + myo-inositol | Gallus gallus | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | Meleagris gallopavo | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | Cavia porcellus | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | Homo sapiens | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | Saccharomyces cerevisiae | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | Oryctolagus cuniculus | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | Rattus norvegicus | enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | Bos taurus | enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol | CMP + phosphatidyl-1D-myo-inositol | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Cavia porcellus | - |
guinea pig | - |
Gallus gallus | - |
chicken | - |
Homo sapiens | - |
human | - |
Meleagris gallopavo | - |
turkey | - |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
rat | - |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Saccharomyces cerevisiae |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Gallus gallus | - |
brain | - |
Cavia porcellus | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
cerebral cortex | - |
Oryctolagus cuniculus | - |
erythrocyte | - |
Meleagris gallopavo | - |
glioma cell | - |
Oryctolagus cuniculus | - |
heart | - |
Gallus gallus | - |
heart | - |
Cavia porcellus | - |
kidney | - |
Cavia porcellus | - |
liver | - |
Gallus gallus | - |
liver | - |
Cavia porcellus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Cavia porcellus | - |
lung | - |
Oryctolagus cuniculus | - |
neuroblastoma cell | - |
Oryctolagus cuniculus | - |
pancreas | - |
Cavia porcellus | - |
pituitary gland tumor cell | GH3 tumour | Rattus norvegicus | - |
placenta | - |
Homo sapiens | - |
spleen | - |
Cavia porcellus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.8 | - |
- |
Rattus norvegicus |
34 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxy-CDP-diacylglycerol + myo-inositol | optimal activity is 25% higher then with CDP-diacylglycerol | Homo sapiens | CMP + ? | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Gallus gallus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Meleagris gallopavo | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Cavia porcellus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Homo sapiens | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Rattus norvegicus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Saccharomyces cerevisiae | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Bos taurus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | - |
Oryctolagus cuniculus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol | Rattus norvegicus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
CDP-diacylglycerol + myo-inositol | enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol | Bos taurus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
additional information | - |
Saccharomyces cerevisiae | ? | - |
? | |
additional information | UDP-diacylglycerol, ADP-diacylglycerol, and GDP-diacylglycerol are inactive as substrates | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | - |
Saccharomyces cerevisiae |
? | ? * 21000, SDS-PAGE | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | 9 | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
diphosphate | - |
Homo sapiens | |
0.8 | - |
phosphate | - |
Homo sapiens |