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Literature summary for 2.7.8.11 extracted from

  • Antonsson, B.E.
    Purification and characterization of phosphatidylinositol synthase from human placenta (1994), Biochem. J., 297, 517-522.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Homo sapiens
ATP
-
Homo sapiens
Ca2+
-
Homo sapiens
CaCl2
-
Homo sapiens
CDP competitive inhibition Homo sapiens
CTP
-
Homo sapiens
diphosphate
-
Homo sapiens
GTP
-
Homo sapiens
additional information AMP CMP, GMP, UMP, TMP, TDP, and GDP are not inhibitory, triphosphates are even more inhibitory than diphosphates Homo sapiens
phosphate
-
Homo sapiens
TTP
-
Homo sapiens
UDP
-
Homo sapiens
UTP
-
Homo sapiens
Zn2+
-
Homo sapiens
ZnCl2
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.28
-
myo-inositol pH 9.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
Golgi apparatus
-
Homo sapiens 5794
-
membrane membrane-bound Homo sapiens 16020
-
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens
Mn2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + myo-inositol Homo sapiens key enzyme in cell membrane biosynthesis CMP + phosphatidyl-1D-myo-inositol
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
34
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, frozen and stored or frozen in liquid nitrogen and subsequently stored, over 50% activity is lost after 24 h Homo sapiens
-60°C, frozen and stored or frozen in liquid nitrogen and subsequently stored, over 50% activity is lost after 24 h Homo sapiens
-80°C, regularly frozen in liqid N2, no detectable loss of activity is experienced during storage at -80°C for up to 2 months Homo sapiens
4°C, stored on ice, 10% of the activity is lost during 24 h Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxy-CDP-diacylglycerol + myo-inositol
-
Homo sapiens CMP + ?
-
r
CDP-diacylglycerol + myo-inositol
-
Homo sapiens CMP + phosphatidyl-1D-myo-inositol
-
r
CDP-diacylglycerol + myo-inositol key enzyme in cell membrane biosynthesis Homo sapiens CMP + phosphatidyl-1D-myo-inositol
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
half-life without substrates 20 min Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
in Tris/HCl buffer, maximal activity is 60% of the activity in glycylglycine/NaOH at pH 9.0, at pH 9.0 almost no activity in Tris/HCl buffer Homo sapiens
9
-
in glycylglycine/NaOH or glycine/NaOH buffer Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.2
-
diphosphate pH 9.0, 37°C Homo sapiens
0.6
-
phosphate pH 9.0, 37°C Homo sapiens
0.6
-
CaCl2 pH 9.0, 37°C Homo sapiens
0.8
-
phosphate
-
Homo sapiens
1.4
-
ATP pH 9.0, 37°C Homo sapiens
1.4
-
UTP pH 9.0, 37°C Homo sapiens
1.4
-
TTP pH 9.0, 37°C Homo sapiens
1.6
-
GTP pH 9.0, 37°C Homo sapiens
1.8
-
CTP pH 9.0, 37°C Homo sapiens
2
-
ZnCl2 pH 9.0, 37°C Homo sapiens
3.8
-
UDP pH 9.0, 37°C Homo sapiens
4
-
CDP pH 9.0, 37°C Homo sapiens
4.1
-
ADP pH 9.0, 37°C Homo sapiens