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Literature summary for 2.7.8.11 extracted from
- Characterization of the forward and reverse reactions catalyzed by CDP-diacylglycerol:inositol transferase in rabbit lung tissue (1979), Biochim. Biophys. Acta, 575, 135-147.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Oryctolagus cuniculus |  |
| Cetylpyridinium chloride | - |
Oryctolagus cuniculus | |
| Sodium dodecyl sulfate | - |
Oryctolagus cuniculus | |
| Triton X-100 | - |
Oryctolagus cuniculus | |
| Tween 20 | - |
Oryctolagus cuniculus | |
| Tween 80 | - |
Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
myo-inositol | pH 8.5, 37°C | Oryctolagus cuniculus | |
| 0.18 | - |
CDP-diacylglycerol | pH 8.5, 37°C | Oryctolagus cuniculus | |
| 2.8 | - |
CMP | pH 8.5, 37°C | Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Oryctolagus cuniculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | reaction and reverse reaction dependent on either Mg2+ or Mn2+ | Oryctolagus cuniculus | |
| Mn2+ | reaction and reverse reaction dependent on either Mn2+ or Mg2+ | Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-diacylglycerol + myo-inositol | Oryctolagus cuniculus | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
rabbit, New Zealand white | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Oryctolagus cuniculus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, substantial loss of enzymic activity when stored for more than 48 h | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-diacylglycerol + myo-inositol | - |
Oryctolagus cuniculus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
| CDP-dioleoylglycerol + myo-inositol | - |
Oryctolagus cuniculus | CMP + dioleoylphosphatidylinositol | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | - |
pH optimum for reverse reaction | Oryctolagus cuniculus |
| 8.8 | 9.4 | - |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 9.5 | at pH 7.0 activity is approximately one-fourth that observed at optimum pH 8.8, enzyme is equally active at pH 8.5 | Oryctolagus cuniculus |
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