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Literature summary for 2.7.7.B22 extracted from
- A high-capacity adenoviral hybrid vector system utilizing the hyperactive sleeping beauty Transposase SB100X for enhanced integration (2016), Mol. Ther. Nucleic Acids, 5, e337 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | plasmid based delivery of the sleeping beauty transposase SB100X system reveals significantly increased integration efficiencies compared with the hyperactive sleeping beauty transposase HSB5. Up to eightfold and 100fold increased integration efficiencies are observed compared with the hyperactive SB transposase HSB5 and the inactive transposase mSB, respectively. Transposon copy numbers per cell are doubled with SB100X compared with HSB5. This hybrid vector system represents a tool for achieving stabilized transgene expression in cycling cells and for treatment of numerous genetic disorders | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SB100X | - |
Homo sapiens |
| sleeping beauty transposase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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