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Literature summary for 2.7.7.88 extracted from

  • Ogino, M.; Ito, N.; Sugiyama, M.; Ogino, T.
    The rabies virus L protein catalyzes mRNA capping with GDP polyribonucleotidyltransferase activity (2016), Viruses, 8, 144.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
F1285A mutation abolishes RNA capping activity Lyssavirus rabies
G1112A mutation abolishes RNA capping activity Lyssavirus rabies
H1241A mutation abolishes RNA capping activity Lyssavirus rabies
Q1286A mutation abolishes RNA capping activity Lyssavirus rabies
R1242A mutation abolishes RNA capping activity Lyssavirus rabies
S1155A about 10% of wild-type activity Lyssavirus rabies
S1168A about 10% of wild-type activity Lyssavirus rabies
T1170A mutation abolishes RNA capping activity Lyssavirus rabies
W1201A mutation abolishes RNA capping activity Lyssavirus rabies

Organism

Organism UniProt Comment Textmining
Lyssavirus rabies Q9IPJ5
-
-
Lyssavirus rabies Nishigahara RCEH Q9IPJ5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-triphospho-mRNA + GDP
-
Lyssavirus rabies diphosphate + guanosine 5'-triphospho-mRNA
-
?
5'-triphospho-mRNA + GDP
-
Lyssavirus rabies Nishigahara RCEH diphosphate + guanosine 5'-triphospho-mRNA
-
?
additional information rabies virus large structural protein shows guanosine 51-triphosphatase and GDP polyribonucleotidyltransferase activities. Enzyme caps 5'-triphosphorylated but not 5'-diphosphorylated RABV mRNA-start sequences, 5'-AACA(C/U), with GDP to generate the 5'-terminal cap structure G(5')ppp(5')A. The 5'-AAC sequence in the substrate RNAs is strictly essential for RNA capping with the RABV L protein Lyssavirus rabies ?
-
?
additional information rabies virus large structural protein shows guanosine 51-triphosphatase and GDP polyribonucleotidyltransferase activities. Enzyme caps 5'-triphosphorylated but not 5'-diphosphorylated RABV mRNA-start sequences, 5'-AACA(C/U), with GDP to generate the 5'-terminal cap structure G(5')ppp(5')A. The 5'-AAC sequence in the substrate RNAs is strictly essential for RNA capping with the RABV L protein Lyssavirus rabies Nishigahara RCEH ?
-
?