Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli XL1 Blue | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
vapor diffusion technique, PEG600, 20°C, pH5.7 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R115A | activity drastically affected | Homo sapiens |
R115A | activity drastically affected, no dimer formation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0053 | - |
N-acetylglucosamine 1-phosphate | wild type protein, pH 8.0, 30°C | Homo sapiens | |
0.006 | - |
N-acetylglucosamine 1-phosphate | wild type protein, pH 8.0, 30°C | Homo sapiens | |
0.032 | - |
UDP-N-acetylglucosamine | wild type protein, pH 8.0, 30°C | Homo sapiens | |
0.049 | - |
UTP | wild type protein, pH 8.0, 30°C | Homo sapiens | |
0.053 | - |
UTP | wild type protein, pH 8.0, 30°C | Homo sapiens | |
0.5 | - |
UDP-N-acetyl-alpha-D-galactosamine | wild type protein, pH 8.0, 30°C | Homo sapiens | |
0.53 | - |
UDP-N-acetyl-alpha-D-galactosamine | wild type protein, pH 8.0, 30°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
74000 | - |
gel filtration | Homo sapiens |
74000 | - |
2 * 74000, gel filtration | Homo sapiens |
120000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q16222 | - |
- |
Purification (Comment) | Organism |
---|---|
anion exchange, phenyl interaction and gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Homo sapiens | - |
cartilage | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.9 | - |
R115A mutant protein, pH 8.0, 30°C | Homo sapiens |
1.5 | - |
R115A mutant protein, pH 8.0, 30°C | Homo sapiens |
68 | - |
wild type protein, pH 8.0, 30°C | Homo sapiens |
69 | - |
wild type protein, pH 8.0, 30°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diphosphate + UDP-N-acetyl-alpha-D-galactosamine | - |
Homo sapiens | UTP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
r | |
diphosphate + UDP-N-acetylglucosamine | - |
Homo sapiens | UTP + N-acetylglucosamine 1-phosphate | - |
r | |
UTP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
Homo sapiens | diphosphate + UDP-N-acetyl-alpha-D-galactosamine | - |
r | |
UTP + N-acetylglucosamine 1-phosphate | - |
Homo sapiens | diphosphate + UDP-N-acetylglucosamine | - |
r |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 74000, gel filtration | Homo sapiens |
monomer | 74000, gel filtration | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
N-acetylglucosamine 1-phosphate uridyltransferase | - |
Homo sapiens |
UAP1 | - |
Homo sapiens |
UDP-N-acetylglucosamine pyrophosphorylase AGX1 | alternatively spliced isoform to AGX2, differs from those referenced in the literature by one change: S445G (most probably a gene polymorphism) | Homo sapiens |
UDP-N-acetylglucosamine pyrophosphorylase AGX2 | alternatively spliced isoform to AGX1, differs from those referenced in the literature by two changes: S445G and Q454S (most probably a gene polymorphism) | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
180 | - |
UDP-N-acetyl-alpha-D-galactosamine | wild type protein, pH 8.0, 30°C | Homo sapiens | |
200 | - |
UDP-N-acetyl-alpha-D-galactosamine | wild type protein, pH 8.0, 30°C | Homo sapiens | |
1200 | - |
UTP | wild type protein, pH 8.0, 30°C | Homo sapiens | |
1400 | - |
UTP | wild type protein, pH 8.0, 30°C | Homo sapiens | |
2000 | - |
UDP-N-acetylglucosamine | wild type protein, pH 8.0, 30°C | Homo sapiens | |
2200 | - |
UDP-N-acetylglucosamine | wild type protein, pH 8.0, 30°C | Homo sapiens | |
11200 | - |
N-acetylglucosamine 1-phosphate | wild type protein, pH 8.0, 30°C | Homo sapiens | |
12200 | - |
N-acetylglucosamine 1-phosphate | wild type protein, pH 8.0, 30°C | Homo sapiens |