Literature summary for 2.7.7.8 extracted from

Becket, E.; Tse, L.; Yung, M.; Cosico, A.; Miller, J.H.
Polynucleotide phosphorylase plays an important role in the generation of spontaneous mutations in Escherichia coli (2012), J. Bacteriol., 194, 5613-5620.

Search for more literature for 2.7.7.8

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
RNAn+1 + phosphate	Escherichia coli	-	RNAn + a nucleoside diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
RNAn+1 + phosphate	-	Escherichia coli	RNAn + a nucleoside diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
PNP	-	Escherichia coli

General Information

General Information	Comment	Organism
malfunction	spontaneous mutations resulting from replication errors, which are normally repaired by the mismatch repair system, are sharply reduced in a polynucleotide phosphorylase-deficient Escherichia coli strain	Escherichia coli
additional information	the increase in the rNDP pools generated by polynucleotide phosphorylase degradation of RNA is responsible for the spontaneous mutations observed in an mismatch repair-deficient background, and is also responsible for the observed mutations in the mutT mutator background and those that occur after treatment with 5-bromodeoxyuridine	Escherichia coli
physiological function	polynucleotide phosphorylase plays a central role in RNA degradation, generating a pool of ribonucleoside diphosphates that can be converted to deoxyribonucleoside diphosphates by ribonucleotide reductase	Escherichia coli

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Release 2023.1 (January 2023)