Literature summary for 2.7.7.8 extracted from

Chan, I.; Lebedeva, I.V.; Su, Z.Z.; Sarkar, D.; Valerie, K.; Fisher, P.B.
Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppression (2008), J. Cell. Physiol., 215, 401-409.

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Application

Application	Comment	Organism
medicine	the promoter of Progression Elevated Gene-3 functions selectively in a diverse array of human cancer cells. An adenovirus constructed with the Progression Elevated Gene-3 promoter driving expression of polyribonucleotide phosphorylase containing a C-terminal hemaglutinin-tag induces robust transgene expression, growth suppression, apoptosis, and cell-cycle arrest in a broad panel of pancreatic cancer cells, with minimal effects in normal immortalized pancreatic cells. Expression correlates with arrest in the G2/M phase of the cell cycle and up-regulation of the cyclin-dependent kinase inhibitors p21CIP1/WAF-1/MDA-6 and p27KIP1. In a nude mouse xenograft model,construct injections effectively inhibit growth of human pancreatic cancer cells in vivo	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	the promoter of Progression Elevated Gene-3 functions selectively in a diverse array of human cancer cells. An adenovirus constructed with the Progression Elevated Gene-3 promoter driving expression of polyribonucleotide phosphorylase containing a C-terminal hemaglutinin-tag induces robust transgene expression, growth suppression, apoptosis, and cell-cycle arrest in a broad panel of pancreatic cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)