Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme depletion using RNAi does not affect mitochondrial RNA levels but impairs mitochondrial electrochemical membrane potential, decreases respiratory chain activity and correlates with altered mitochondrial morphology. This results in F0F1-ATP synthase instability, impaired ATP generation, lactate accumulation, and AMP kinase phosphorylation with reduced cell proliferation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | localizes to the intermembrane space of mitochondria as a peripheral membrane protein in a multimeric complex | Homo sapiens | 16020 | - |
mitochondrion | basal and interferon-beta induced enzyme is efficiently imported into mitochondria with coupled processing of the N-terminal targeting sequence. It localizes to the intermembrane space as a peripheral membrane protein in a multimeric complex | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant enzyme | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | processing of the N-terminal targeting sequence upon import into mitochondria | Homo sapiens |