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Literature summary for 2.7.7.8 extracted from

  • Sarkar, D.; Park, E.S.; Fisher, P.B.
    Defining the mechanism by which IFN-beta dowregulates c-myc expression in human melanoma cells: pivotal role for human polynucleotide phosphorylase (hPNPaseold-35) (2006), Cell Death Differ., 13, 1541-1553.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interferon-beta close association between interferon-beta induced upregulation of enzyme and c-myc downregulation Homo sapiens

Application

Application Comment Organism
medicine depletion of enzyme by RNAi approach or overexpression of c-myc protects melanoma cells from interferon-beta mediated grwoth inhibition. Targeted overexpression of enzyme as a therapeutic strategy for c-myc overexpressing and interferon-beta resistant tumors Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information depletion of enzyme by RNAi approach or overexpression of c-myc protects melanoma cells from interferon-beta mediated grwoth inhibition. Targeted overexpression of enzyme as a therapeutic strategy for c-myc overexpressing and interferon-beta resisitant tumors Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell
-
Homo sapiens
-