Literature summary for 2.7.7.8 extracted from

Mohanty, B.K.; Kushner, S.R.
Polynucleotide phosphorylase functions both as a 3' -> 5' exonuclease and a poly(A) polymerase in Escherichia coli (2000), Proc. Natl. Acad. Sci. USA, 97, 11966-11971.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
RNAn + a nucleoside diphosphate	Escherichia coli	PNPase synthesizes long, highly heteropolymeric poly(A) tails in vivo and accounts for all of the residual polyadenylylation in poly(A) polymerase deficient strains, in addition PNPase is responsible for adding the C and U residues that are found in poly(A) tails in exponentially growing wild-type cultures	RNAn+1 + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	PNPase is one of the cold shock-induced proteins in Escherichia coli, pnp gene encoding PNPase is essential for growth at low temperatures	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
RNAn + a nucleoside diphosphate	PNPase synthesizes long, highly heteropolymeric poly(A) tails in vivo and accounts for all of the residual polyadenylylation in poly(A) polymerase deficient strains, in addition PNPase is responsible for adding the C and U residues that are found in poly(A) tails in exponentially growing wild-type cultures	Escherichia coli	RNAn+1 + phosphate	-	?

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Release 2023.1 (January 2023)