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Literature summary for 2.7.7.7 extracted from

  • Castrec, B.; Laurent, S.; Henneke, G.; Flament, D.; Raffin, J.P.
    The glycine-rich motif of Pyrococcus abyssi DNA polymerase D is critical for protein stability (2010), J. Mol. Biol., 396, 840-848.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information the (G)-PYF box is located in a hydrophobic region close to the active site. The (G)-PYF box mutants exhibit altered DNA binding properties. In addition, the thermal stability of all mutants is reduced compared to that of wild type, and this effect could be attributed to increased exposure of the hydrophobic region Pyrococcus abyssi

Organism

Organism UniProt Comment Textmining
Pyrococcus abyssi
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Synonyms

Synonyms Comment Organism
DNA polymerase D
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Pyrococcus abyssi
PabPol D
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Pyrococcus abyssi

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
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the (G)-PYF box motif mediates intersubunit interactions, which may be crucial for the thermostability of the enzyme Pyrococcus abyssi