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Literature summary for 2.7.7.7 extracted from
- Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases (2007), J. Mol. Biol., 372, 855-863.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hypoxanthine | traces of uracil and hypoxanthine in DNA can lead to inhibition of the polymerase chain reaction by archaeal DNA polymerases | Pyrococcus furiosus |  |
| Uracil | traces of uracil and hypoxanthine in DNA can lead to inhibition of the polymerase chain reaction by archaeal DNA polymerases | Pyrococcus furiosus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pyrococcus furiosus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pyrococcus furiosus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | polymerase binds DNA containing uracil 1.54.5-fold more strongly than hypoxanthine | Pyrococcus furiosus | ? | - |
? | |
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Release 2023.1 (January 2023)
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