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BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Kokoska, R.J.; McCulloch, S.D.; Kunkel, T.A.
    The efficiency and specificity of apurinic/apyrimidinic site bypass by human DNA polymerase eta and Sulfolobus solfataricus Dpo4 (2003), J. Biol. Chem., 278, 50537-50545.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q97W02
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn bypass of apurinic/apyrimidinic sites lacking A or G is nearly 100% mutagenic. The majority (70–80%) of bypass events are insertion of dAMP opposite the apurinic/apyrimidinic site Saccharolobus solfataricus diphosphate + DNAn+1
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Synonyms

Synonyms Comment Organism
DNA polymerase 4
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Saccharolobus solfataricus
Dpo4
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Saccharolobus solfataricus