Literature summary for 2.7.7.7 extracted from

Cruet-Hennequart, S.; Gallagher, K.; Sokol, A.M.; Villalan, S.; Prendergast, A.M.; Carty, M.P.
DNA polymerase eta, a key protein in translesion synthesis in human cells (2010), Subcell. Biochem., 50, 189-209.

Search for more literature for 2.7.7.7

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
78410	-	estimated from amino acid sequence	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y253	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	human DNA polymerase eta expression is detected in most tissues except for very low or undetectable levels in peripheral lymphocytes, fetal spleen, and adult muscle	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Homo sapiens	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase eta	-	Homo sapiens
Pol eta	-	Homo sapiens
PolH	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	DNA polymerase eta expression is induced by cisplatin, mRNA expression can be up-regulated in a p53-dependent manner following ionizing radiation or camptothecin treatment	up

General Information

General Information	Comment	Organism
malfunction	DNA polymerase eta-deficient cells show strong activation of downstream DNA damage responses including ataxia-telangiectasia mutated and Rad3-related protein signaling and accumulate strand breaks as result of replication fork collapse	Homo sapiens
physiological function	DNA polymerase eta is a key protein in translesion synthesis in human cells, it is a low-fidelity enzyme when copying undamaged DNA but can carry out error-free translesion synthesis at sites of UV-induced dithymine cyclobutane pyrimidine dimmers. DNA polymerase eta plays an important role in preventing genome instability after UV- and cisplatin-induced DNA damage	Homo sapiens

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Release 2023.1 (January 2023)